Take the QEW to exit 38 and follow the signs to Highway 55 and into town as above. OR - follow the signs at the Peace Bridge to the scenic Niagara Parkway and follow it from Fort Erie right into Niagara-on-the-Lake.
Via Niagara Falls:
Cross the Rainbow Bridge and follow the signs to the Niagara Parkway north to Niagara-on-the-Lake.
Cross the Queenston-Lewiston Bridge and follow the signs to the Niagara Parkway north to Niagara-on-the-Lake.
Take Highway 401 and 403 to Hamilton, Ontario and then follow directions from Toronto ("Shown Below") down the QEW to Niagara-on-the-Lake.
From Toronto and destinations east/west via Hwy 401
Follow the QEW towards Niagara. After crossing the Garden City Skyway at St. Catharines, exit the QEW at exit 38B and follow the Niagara-on-the-Lake signs to Highway 55. Take Highway 55 12km(7mi) northeast, pass through Virgil, and proceed into the town of Niagara-on-the-Lake.